Pyrano Fused Coumarins: an Exclusive Synthesis from Simple Micheal Addition of 4-Hydroxy Coumarin to ?,? – Unsaturated Carbonyl Compound and Screening of MCF-7 Cell Viability by MTT Assay
Abstract
The Micheal Addition of 4-hydroxy coumarin to various 3-aryl-1-(pyridin-3-yl)prop-2-en-1-ones and various 3-aryl-1-(pyridin-4-yl)prop-2-en-1 under presence of Iodine and Acetic Acid gives various pyrano[3,2-c]coumarins in good yields. The synthesized compounds were characterized by spectroscopic study and screened for MCF-7 (breast cancer) cell line prevention Analysis of cell viability by MTT assay.