Evaluation of Invitro Antidiabetic and Antioxidant activity Using Methanolic Extract of Medicinal Plants (Senna alata and Senna hirsuta)

Authors

  • D.Madankumar, S. Pari

Abstract

In diabetic physiopathology, oxidative stress plays an important role, so there is interest in using natural antioxidants as therapeutic tools. The evaluation aims to evaluate antioxidant activity and related studies of Senna alata and Senna hirsuta organic extracts. Antioxidant action was carried out with radicals of 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and ferric reduction / antioxidant power (FRAP) ways. An in vitro model was used to study the ?-amylase inhibitory assay. In addition, previous phytochemical analyzes of the tested extracts were performed. Senna alata exhibited the highest antioxidant activity, IC50= 430.56 ?g / mL and IC50= 612.05 ?g / mL, respectively for the ABTS and Reducing power assay ways. However, the Senna alata fraction methanolic extract had the highest inhibitory effect towards an inhibitory ?-amylase assay (IC50=446.10 ?g/mL). It is inferred from the results that these herbs could be a major basis of natural homeopathically useful ones. Thus, it is inferred that the antioxidant elements present, has strong potential in hyperglycemia, diabetes and the associated oxidative stress disorder treatments. The information expedient the clinical development of antidiabetic therapies in discovering more effective antidiabetic concepts from the natural resources.

Published

2020-10-16

Issue

Section

Articles